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06/18/2026

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06/13/2026

Scientists removed the extra chromosome that causes Down syndrome from human cells using CRISPR gene-editing.

Led by Dr. Ryotaro Hashizume, the research team achieved "trisomy rescue" by targeting the surplus copy of chromosome 21, which is responsible for the condition's developmental and cognitive challenges.

By deploying precise molecular guides, the team successfully excised the extra chromosome and restored typical cellular functions in over 30% of the treated human cells. This breakthrough represents the first time an entire extra chromosome has been cleared from patient-derived cells, resulting in healthier, faster-growing cells with restored gene expression.

Although the research is in its early stages and currently confined to lab-grown cells, it represents a bold leap forward for precision medicine.

Instead of targeting individual genes, this approach addresses the genetic root of the condition, offering a revolutionary glimpse into future chromosomal therapies. Researchers caution that translating this laboratory success into real-world patient treatments will require extensive safety trials, refined delivery systems, and careful ethical considerations.

Nevertheless, this proof of concept marks a promising step toward potentially altering the trajectory of Down syndrome and other complex genetic conditions.

source: Hashizume, R., Wakita, S., Sawada, H., Takebayashi, S., Kitabatake, Y., Miyagawa, Y., Hirokawa, Y. S., Imai, H., & Kurahashi, H. Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells. PNAS Nexus.

06/08/2026

Today was supposed to be a final goodbye, but Janice, my bold jumping spider, had a different plan. After months of caring for her, the moment finally came t...

06/07/2026

EV stats for anyone interested. Detailed here in these pics are from my home level 2 charger in my garage, the 2nd pic is charging at free level 2 chargers around down via charge point. Not including any DC fast charging my total fuel costs for my car for over a year is less than $30

05/30/2026

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05/28/2026

Looks fun

The PowerPod is a revolutionary concept of a paragliding pod harness, featuring a very compact and light-weight engine behind your back which does not interf...

05/28/2026

All electric, vertical takeoff

05/28/2026

Support this channel on Patreon to help me make this a full time job: https://www.patreon.com/whatdamath (Unreleased videos, extra footage, DMs, no ads)Alter...

05/26/2026

hillside earth ships

We explore an innovative Earthship house built in 1990, located at ...

05/26/2026

passive earth ship; collecting water, growing food, retaining comfortable temperature without electricity or consumable heat

Cinematic video of the Phoenix Earthship in Taos, NM. Recorded and ...