MR Solutions

Name: MR Solutions
Address: Old Portsmouth Road, Guildford, GU31LR, GB
Telephone: +44 (0)1483 532146
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MR Solutions

World leader in MRI technology and developer of superconducting, cryogen free MRI systems from 0.1T to 9.4T

World leader in MRI technology and the leading developer of superconducting, cryogen free MRI systems. MRS accessorizes its preclinical MRI scanners with PET and SPECT modules for both sequential and simultaneous acquisition with MR data. The MRS systems offer innovative imaging solutions for preclinical research and provide researchers with insight in their research.

11/09/2024

What an incredible start to the WMIC in Montreal! We invite you to visit our booth and meet our team — we’re excited to share the latest features of our molecular imaging systems.

02/07/2024

We are really pleased to be the UHF sponsor of the 4th ISMRM Iberian Chapter meeting in Porto. Thanks to all for attending the talk from our colleague this morning and for the great questions. We still have some happy little friends 🐭 looking forward to be adopted by preclinical researchers. Please pass by to the booth number 1 😊

08/06/2024

Our new staff looks forward to meeting you at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) in booth 1725. Starting today at 6 p.m. Fabrice Chaumard, Nicky Doughty and Jordan Noble will assist our new recruits for technical questions!

28/05/2024

Congratulations to the authors of this week's Publication Spotlight!
Fei Wang, Xiangyu Zhang, Yang Liu, Zhe Li, Ruixue Wei, Yan Zhang, Ruiyi Zhang, Suliman Kahn, V. Wee Yong, Mengzhou Xue.

We studied the impact of Ozanimod on neuroprotection in an experimental mouse model of ICH. Ozanimod was administered by gavage 2 h after surgery and once a day thereafter until sacrifice. The Ozanimod treatment improved neurobehavioral deficits and decreased weight loss after ICH. Ozanimod significantly reduced the density of activated microglia and infiltrated neutrophils in the perihematoma region. Furthermore, Ozanimod reduced hematoma volume and water content of the ICH brain. The results of TUNEL staining indicate that Ozanimod mitigated brain cell death. The quantitative data of Evans blue (EB) staining showed that Ozanimod reduced EB dye leakage. Overall, Ozanimod reduces the destruction of the BBB and exert neuroprotective roles following ICH in mice.

The data was acquired on an MRS*DRYMAG 4.7T system at The University of Zhengzhou. The article was published in Frontiers in Nuclear Medicine in 2022.

The publication is available at: https://www.frontiersin.org/articles/10.3389/fnmol.2022.927150/full

21/05/2024

Congratulations to the authors of this week's Publication Spotlight!
Kathryn E. Anderssen, Mathias Kranz, Shaheen Syed, Svein Kristian Stormo.

The fiber structure of tissue in meat and seafood has a significant impact on their perceived quality. We investigate diffusion tensor imaging (DTI) MRI as a method to quantitatively describe tissue structure. DTI measures the anisotropy of water molecule diffusion within muscle fibers. A pilot study on cod loin samples showed clear differences in DTI parameters between high, medium, and poor quality samples. DTI detected details not visible in traditional MRI, indicating its promise for characterizing tissue structure in seafood and meat.

The data was acquired on an MRS*DRYMAG 7T, large bore 24 cm, at the Arctic University of Norway. The article was published in Food Chemistry in 2022.

The publication is available at: https://doi.org/10.1016/j.foodchem.2022.132099

14/05/2024

Congratulations to the authors of this week's Publication Spotlight!
Jamie Zagozewski, Ghazaleh Shahriary, Ludivine Morrison, Margaret Stromecki, Agnes Fresnoza, Gareth Palidwor, Christopher Porter, Antoine Forget, Olivier Ayrault, Cynthia Hawkins, Jennifer Chan, Olivier Saulnier, Maria Vladoiu, Michael Taylor, Vijay Ramaswamy, Tamra Werbowetski-Ogilvie

OTX2 is a potent oncogene that promotes tumour growth in Group 3 medulloblastoma, via not-well characterized mechanisms. This publication shows an extensive multiomic analysis to identify an OTX2 regulatory network that controls Group 3 medulloblastoma cell fate. One of these involves an increase in the expression of neurodevelopmental transcription factors including PAX3 and PAX6. Expression of PAX3 and PAX6 is signiﬁcantly lower in Group 3 medulloblastoma patients and is correlated with reduced survival, yet only PAX3 inhibits self-renewal in vitro and increases survival in vivo. Identiﬁcation of mTORC1 signalling as a downstream effector of OTX2-PAX3 reveals roles for protein synthesis pathways in regulating Group 3 medulloblastoma pathogenesis.

The data was acquired on a MRS*DRYMAG 7T with a clip-on PET system at the university of Manitoba. The article was published in Nature Communications in 2020.
The publication is available at: https://doi.org/10.1093/neuonc/noz175.804

02/05/2024

Hej Copenhagen, and welcome to the family to Julie van Krimpen Mortensen, Cecilie Høeg Pedersen,Tina Binderup, Emil Nørgaard Christensen and Andreas Høeg Clemmensen who completed their training on their new MRS*DRYMAG 24cm bore paired with a large bore PET insert for simultaneous imaging on whole body rats and multiple mice.
Can't wait to see the exciting results the University of Copenhagen Department of Biomedical Sciences Cluster for Molecular Imaging brings!

30/04/2024

Congratulations to the authors of this week's Publication Spotlight!
Alan Courteau, John McGrath, Paul Michael Walker, Benoît Presles, Ruslan Garipov, Alexandre Cochet, François Brunotte, Jean Marc Vrigneaud
The use of preclinical simultaneous PET/MR imaging systems is on the rise, transitioning from physicists to pharmacology and biology experts. However, these combined scanners are susceptible to artifacts and performance deviations due to external factors or subsystem interference, potentially affecting image quality and data accuracy.
Quality assurance is essential to prevent loss of animals and experiments. To streamline this process, simple daily tests have been developed over the past 5 years for easy implementation by experimenters with limited technical expertise. Additional periodic tests are recommended for comprehensive system maintenance, using cost-effective materials for accessibility.

The data was acquired on a MRS*DRYMAG 7T with integrated PET insert system at the CGFL. The article was published in Molecular Imaging and Biology in 2022.
The publication is available at: https://doi.org/10.1007/s11307-022-01787-1

24/04/2024

We will be attending the ISMRM in Singapore on the 4th to 9th of May. Pop by booth D26 to discuss how our technology can take your imaging to the next level with our friendly team!
More details on the conference's website: https://www.ismrm.org/24m/
Come and say hi!

18/04/2024

Congratulations to the authors of this week's Publication Spotlight!
Aurea Pascal, Ningrui Li, Kendra J. Lechtenberg, Jarrett Rosenberg, Raag D. Airan, Michelle L. James, Donna M. Bouley and Kim Butts Pauly

The study investigated the inflammatory response to blood-brain barrier (BBB) opening using pulsed-focused ultrasound and low microbubble doses in mice. Results showed that mild histologic changes and inflammatory response activation occurred at specific acoustic pressures (0.15-0.20 MPa) regardless of microbubble dose. Higher acoustic pressures led to more severe activation, indicating the importance of considering potential inflammatory responses when using ultrasound for BBB opening in therapeutic applications.

The data was acquired on a MRS*DRYMAG 3T system at Stanford University ersity. The article was published in Nanoscale in 2020.
The publication is available at: https://doi.org/10.7150/ntno.49898

16/04/2024

Hello Lithuania!
We are delighted to welcome the Hospital of Lithuanian University of Health Sciences to the MR Solutions family! We can't wait to see the results obtained on their Drymag 3T / PET CLIP-ON802!

11/04/2024

Congratulations to the authors of this week's Publication Spotlight!
Sadi Loai, Beiping Qiang, Michael A. Laﬂamme and Hai-Ling Margaret Cheng

This study aimed to use blood-pool MRI to assess how the heart's microvascular system responds to changes in blood gas levels, specifically looking for differences between male and female subjects. The research involved healthy rats exposed to normoxia and hypercapnia while undergoing MRI scans and laser Doppler perfusion measurements. Results showed that female rats exhibited myocardial vasodilation during hypercapnia, while males did not show significant changes. Both sexes experienced vasoconstriction upon returning to normoxia. The study concluded that blood-pool MRI is effective in detecting these responses and highlighted sex-related differences in how the heart's microcirculation reacts to mild changes in blood gas levels, which could have implications for understanding cardiovascular function and dysfunction.

The data was acquired on a MRS*DRYMAG 3T system at the University of Toronto. The article was published in Frontiers in Cardiovascular Medicine late last year.

The publication is available at: www.doi.org/10.3389/fcvm.2023.1216587

Address

Old Portsmouth Road
Guildford
GU31LR

Telephone

+44 (0)1483 532146

Website

http://www.mrsolutions.com/

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